Some seem to think that you can go off-label with Benadryl and stay safe, provided you use the right dose: “I’d say 700mg+ is a good dose for this but should not exceed 900mg. You could say I'm not that experienced, but I'm experienced enough to know what's going to happen to me physically and mentally when I take those drugs Allergy medicines represent yet another front in the battle over household items that get you high. But Benadryl Pills Get High in the past 6 months I experienced and LOVED the high off of Benadryl (or generic Benadryl brand). Benadryl Pills To Get High. 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I’ve been an addict for a few years and I’ve done it all. However, taking more than 25 mg can be extremely dangerous and is more likely to cause harm than produce any euphoria. Just wanted to inform some people about recreational benefits of Benadryl (diphenhydramine). Diphenhydramine. Verdict: Yes.. Benadryl is sometimes abused by individuals who are looking for an inexpensive and easily accessible “high. By Jessica Cervantez. Snorting pills. When used as a night-time sleeping aid, the usual dosage of Benadryl is 50mg at bedtime There are 25mg of antihistamine in each pill, it would put you into a sleep that you would NOT wake up from Asked Jan 31, 2009 by anonymous. 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